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DURICEF®is a semi-synthetic
cephalosporin-class antibiotic intended for oral administration.
DURICEF is indicated for: pharyngitis and tonsillitis caused
by Streptococcus pyogenes (group A beta-hemolytic streptococci);
skin and skin-structure infections caused by susceptible strains
of staphylococci and/or streptococci; urinary tract infections
caused by Escherichia coli, Proteus mirabilis, and Klebsiella
species.
DURICEF is a pediatric antibiotic
suspension that is titrated according to the patient’s
weight
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Dosing schedules for children
(Total daily dose: 30 mg/kg/day) 5 mL=1 teaspoon |
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lb/kg |
10/4.5 |
20/9.1 |
30/13.6 |
40/18.2 |
50/22.7 |
60/27.3 |
70+/31.8 |
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125mg/
5ml |
1
tsp |
2
tsp |
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|
|
|
|
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250mg/
5ml |
|
1
tsp |
1 1/2
tsp |
2
tsp |
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500mg/
5ml |
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1
tsp |
1 1/4
tsp |
1 1/2
tsp |
2
tsp |
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For pharyngitis/tonsillitis and impetigo, the recommended daily
dosage for children is 30 mg/kg/day in single (QD) or divided
(BID) doses every 12 hours. For urinary tract infections and
for skin/skin structure infections other than impetigo, the
recommended daily dosage for children is 30 mg/kg/day in divided
(BID) doses every 12 hours.
DURICEF Helps Kids Feel Better as They
Get Better
In vitro tests indicate that cephalosporins are bactericidal
because of their inhibition of cell-wall synthesis. Cefadroxil
has been shown to be active against the following organisms
both in vitro and in clinical infections: Beta-hemolytic streptococci,
Staphylococci (including penicillinase-producing strains), Streptococcus
(Diplococcus) pneumoniae, Escherichia coli, Proteus mirabilis,
Klebsiella species.
NOTE: Only penicillin by the intramuscular route of administration
has been shown to be effective in the prophylaxis of rheumatic
fever. DURICEF® is generally effective in the eradication
of streptococcus from the oropharynx. However, data establishing
the efficacy of DURICEF for the prophylaxis of subsequent rheumatic
fever are not available.
Kids May Feel Better About These Additional Benefits:
- The once-daily dosing option may enhance compliance (see dosing chart)
- Pleasant-tasting oral suspension (pineapple-orange flavor)
- Administration without regard to meals
- Low incidence of stomach upsets
The most commonly reported side effects with DURICEF are: rash,
itching, swelling, diarrhea; dyspepsia, nausea and vomiting
have been reported rarely.
Pseudomembranous colitis has been reported with nearly all antibacterial
agents, including cefadroxil, and may range from mild to life-threatening.
Therefore, it is important to consider this diagnosis in patients
who present with diarrhea subsequent to the administration of
antibacterial agents.
In patients with renal impairment, the dosage of DURICEF should
be adjusted according to creatinine rates. DURICEF is contraindicated
in patients with known |
